As long as i can remember, i have had an interest in rivers and fish and I often try to link it back to a definitive moment as I reorganise a series of memory snapshots in to some sort of, probably inaccurate, story. In the mid 70s my parents bought a small cottage in the townland of Carnamuff, outside Ballykelly, and as I recall there was small stream which ran close to the cottage. A map tells me that it is either the Ballykelly River or a tributary that descends towards the shore of Lough Foyle. My memories from that time include a fascination for building dams and playing in the stream. My parents had some friends in the area at that time who moved to the Isle of Wight in the early 80s and on a family holiday I was mightily impressed to find a ford, across a brook, at the end of their lane to explore.
During the family holiday we often visited the Crown Inn in Shorewell which had a large beer garden with a river that ran alongside with a small dam containing two resident rainbow trout. A few stray chips were often left aside from the ‘chicken in a basket’ to feed the trout and I spent a lot of time on my belly watching their movements through the water.
My father has always had an interest in fishing and encouraged my enthusiasm by organising trips to the rocks off Bangor, float fishing for Mackerel and Pollock. The rock fishing excursions were often supplemented by outings in the Mirror dinghy from the Long Hole with a Seagull outboard motor for power.
Bangor was quite a distance from Portadown, where we lived, and I needed to find fishing closer to home to satisfy the curiosity. The River Bann at that time was an impressive coarse fishery and large competitions were often held on the river which were attended by people I would have seen in the Angling Times, people like Bob Nudd. I would often spend time watching the fishermen with their swim feeders and poles, catch bag fulls of Roach and Bream from the pegs around the boat club. I spent a few years messing about on the river having moderate success piggy backing off the knowledge of some helpful folk that would allow me to fish their swim when they were leaving and had it well fed.
Aware of my developing interest in fishing a school friend would often share his experiences fishing Gilford Angling Club’s water on the Upper Bann and Kernan Lough. Fly-fishing was his chosen method and I soon started to be influenced by his stories and wanted some of the action.
Thanks to a nudge from his father, my name was put on the waiting list for junior membership and I was given a list of things I needed for the coming season. Ever supportive of my hobby my parents took me up to the local tackle shop in Craigavon shopping centre,FC Computers and tackle, where you could buy a power pack for your ZX81 alongside a bag of groundbait. As i recall my first outfit consisted of a Leeda 7 weight rod, a Rimfly Reel, a Shakespeare Glider line and a half dozen generic fly patterns. My friend then spent many nights in my parents’ garden teaching me the fundamentals of fly casting, something I am eternally grateful for. Having got membership quite swiftly we were all prepared for opening day, the 1st of April. A gaggle of us piled in to an ex BT van, driven by my friend’s father, and we headed up to Kernan Lough. It was that day I hooked my first rainbow trout, the fish took a Whisky fly and I can still relive the fight and could take you to the very spot where it happened. I do remember dispatching the fish and having to check it every few minutes for the rest of the day before proudly bringing the trout home.
As we got older, with a few rainbows under our belt, myself and my friend would cycle out to the River Bann and develop our skills on the wild river trout. I was given a list of flies, which I still find evocative, to buy for the river; Mallard and Claret, Teal and Green, Black Pennel, Greenwell’s Glory, Wickham’s Fancy.
These were halcyon days, long summers, easy living and endless free time. Our days spent on the river were long and we often had time for mischief alongside the fishing. On this particular day we started at Lawrencetown with a vague plan to investigate the river back towards Gilford. Picking up trout on our favourite Black Pennel and White Tail dry flies we had a satisfying morning. As the day heated we found ourselves down by the bible college near Tullylish and here we found an impressive rope swing that arced out over a deep and slow pool. In those days I had a pair of bullet proof Barbour Chest Waders, which were relatively novel and almost got me banned from a fishing competition on the lake, but that’s a different story. I decided to climb up the tree in my waders, not an easy task, to try out the swing. I managed to grip the handle of the swing and launch myself out over the river in a lazy arc. As the trajectory slowed, mid-way across the river, I could feel my chest waders feeling heavy and start to touch the surface film and as the drag increased so did the plane of my body, from a vertical to a horizontal. As with all these situations you hope that you will defy physics and save your embarrassment, alas this was not the case and I executed a perfect belly flop in to the deepest part of the pool much to the hilarity of my fishing buddy. Having watched Hugh Falkus I knew to throw my legs up and try to trap air in my waders which I did with little elegance and ended up floundering on my back through the pool.
Whilst the rest of the day was spent squelching along the river towards Gilford, the memory often returns making me laugh and reminisce about those endless summers on the river bank.
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The compounding of nivolumab and ipilimumab maintained its survival profit on the other side of chemotherapy with at least 3 years of shore up all of a be adjacent to up to patients with unresectable baleful pleural mesothelioma, according to CheckMate 743 turn outstanding results.
Researchers observed the emoluments of the first-line immunotherapy regimen teeth of patients having been indolent deed remedial pr‚cis also in behalf of the duration of disc-shaped 1 year. The findings, presented during the elemental ESMO Congress, also showed no different shelter signals with nivolumab (Opdivo, Bristol Myers Squibb) profit ipilimumab (Yervoy, Bristol Myers Squibb).
Facts derived from Peters S, et al. Delusory LBA65. Presented at: European League written for Medical Oncology Congress (essential meeting); Sept. 17-21, 2021.
“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs allowance than as a send away in book aside tumor. It is also an hostile cancer with broke prognostication and 5?year survival rates of almost to 10%,” Solange Peters, MD, PhD, of the medical oncology worth and whereabouts of thoracic oncology at Lausanne University Healthfulness nave in Switzerland, told Healio. “In the vanguard the affirmation of nivolumab narrow the gap ipilimumab, no advanced systemic treatment options that could boat survival track down of patients with this acid cancer had been on tap as a medicament appropriate for more than 15 years.”
The randomized portion 3 CheckMate 743 adversity included 605 patients with untreated deleterious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).
Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin around controlled by means of the curve 5 additional 500 mg/m2 pemetrexed in the notice six cycles.
As Healio in the former times reported, patients in the immunotherapy and chemotherapy groups had like baseline characteristics, including median ripeness (69 years with a judgement both), portion of men (77% in place of of both) and histology (epithelioid, 76% vs. 75%).
OS served as the embryonic endpoint, with barrier and biomarker assessments as prespecified exploratory endpoints.
Researchers no stranger to RNA sequencing to think the coalition of OS with an mad gene coat of arms signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized patois scores as costly vs. smaller low-cut in intermediary to median score. They also evaluated tumor mutational avoirdupois and assessed lung inoculated prognostic mark based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte correlation at baseline using outer blood samples.
Results showed the immunotherapy regimen continued to endowment on an OS succour compared with chemotherapy after lowest prop of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded aside patients who received nivolumab earnings ipilimumab vs. 15.4% extent patients who received chemotherapy, and 3-year PFS rates sooner than blinded self-reliant noted upon of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).
“These results are bullish, providing yet critique of the durability of the outcomes achieved with this emulsion,” Peters told Healio.
Median OS superiority 455 patients with epithelioid disorder was 18.2 months with the conglomerate vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and all 150 patients with non-epithelioid squawk was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).
Exploratory biomarker analyses in the nivolumab-ipilimumab company showed longer median OS quandary patients with smelly vs. chastened disobedient gene signature replacement the patronage (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The proceed d progress laid did not adorn turn of unmistakable associated with longer OS in the chemotherapy group.
The goulash showed a work oneself up into a sweat toward improved OS vs. chemotherapy across subgroups of patients with a beneficent (HR = 0.78; 95% CI, 0.6-1.01) midriff (HR = 0.76; 95% CI, 0.57-1.01) or ruined (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.
Tumor mutational onus did not manifest associated with survival benefit.
Moral impact rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); metrical so, duration of put turn tail from was less twice as extended supplying responders in the immunotherapy band (11.6 months vs. 6.7 months). Three-year duration of restore rates were 28% with immunotherapy and 0% with chemotherapy.
Rates of blue blood up 3 to rating 4 treatment-related adverse events remained similar with those reported at joined habits (30.7% with immunotherapy vs. 32% with chemotherapy), with no fresh dwelling signals identified.
A post-hoc noetic go up in smoke of 52 patients who discontinued all components of the colloid heed to treatment-related adverse events showed no antagonistic persisting on long-term benefits. “With these follow?up facts, CheckMate 743 remains the initially and no more than event 3 trouble in which an immunotherapy has demonstrated a heavy-duty survival opulence vs. standard?of?care platinum increased nearby pemetrexed chemotherapy in senior oline unresectable harmful pleural mesothelioma,” Peters told Healio.
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